{"id":200,"date":"2018-08-23T12:18:55","date_gmt":"2018-08-23T02:48:55","guid":{"rendered":"https:\/\/blogs.flinders.edu.au\/fcic-now\/?p=200"},"modified":"2018-08-23T16:15:16","modified_gmt":"2018-08-23T06:45:16","slug":"cell-screen-sa-international-nis-collaboration","status":"publish","type":"post","link":"https:\/\/blogs.flinders.edu.au\/fcic-now\/2018\/08\/23\/cell-screen-sa-international-nis-collaboration\/","title":{"rendered":"Cell Screen SA international NIH collaboration"},"content":{"rendered":"<figure id=\"attachment_214\" aria-describedby=\"caption-attachment-214\" style=\"width: 300px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-214 size-medium\" src=\"https:\/\/blogs.flinders.edu.au\/fcic-now\/wp-content\/uploads\/sites\/73\/2018\/08\/CellScreencroppedresized-for-blog-300x199.jpg\" alt=\"\" width=\"300\" height=\"199\" srcset=\"https:\/\/blogs.flinders.edu.au\/fcic-now\/wp-content\/uploads\/sites\/73\/2018\/08\/CellScreencroppedresized-for-blog-300x199.jpg 300w, https:\/\/blogs.flinders.edu.au\/fcic-now\/wp-content\/uploads\/sites\/73\/2018\/08\/CellScreencroppedresized-for-blog-768x509.jpg 768w, https:\/\/blogs.flinders.edu.au\/fcic-now\/wp-content\/uploads\/sites\/73\/2018\/08\/CellScreencroppedresized-for-blog.jpg 1024w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-214\" class=\"wp-caption-text\">CeSSA&#8217;s Dr Bracho Granado &amp; Dr Amanda Aloia.<\/figcaption><\/figure>\n<p>The NIH project aims to determine how reproducible high-throughput screening is. All of the laboratories involved will run the same protocols and results will be compared.\u00a0 Other current projects include; characterising drugs previously found to be effective against zika virus replication, preparing to test drugs against a model of breast cancer, and preparing to conduct some high throughput studies on a model relevant to lupus.<\/p>\n<p>CeSSA is a unique research facility on level 4 of\u00a0Flinders Centre for Innovation in Cancer\u00a0building that has specialised equipment enabling a high number of cell-culture based models of human disease to be performed very quickly.\u00a0 For example, thousands of different drug treatments or thousands of single gene changes within the cells being studied can be tested.\u00a0 This is called high-throughput screening.\u00a0 The service is available to any medical researcher and Cell Screen SA collaborates with groups from every South Australian academic institute.<\/p>\n<p>Dr Amanda Aloia tells us \u201cwe have the great enjoyment and challenge of working across multiple research areas, including cancer, virology and immunology. One type of project we commonly work on is to test known drugs on new models of human disease. Drugs which can treat one disease may actually be capable of treating another also \u2013 this is called \u201cdrug repurposing\u201d and, since the drugs have already been clinically-approved and\/or have a known mechanism of action, it may provide a faster path from the laboratory to the clinic. One example of this is a project in which we tested approximately 3000 known drugs on a special model of acute lympoblastic leukemia (ALL). This project used cells with the same specific genetic modification that is found in patients with high-risk ALL. This type of ALL has a low survival rate and a greater risk of relapse. Our collaborators are currently characterising the drugs we found that reduced the growth of these ALL-type cells.\u201d<\/p>\n<p><a href=\"http:\/\/www.flinders.edu.au\/medicine\/research\/facilities\/cell-screen-sa.cfm\">For further\u00a0information\u00a0and contact details for Cell Screen SA click here.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The NIH project aims to determine how reproducible high-throughput screening is. All of the laboratories involved will run the same protocols and results will be compared.\u00a0 [&hellip;]<\/p>\n","protected":false},"author":1138,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-200","post","type-post","status-publish","format-standard","hentry","category-uncategorised"],"post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/blogs.flinders.edu.au\/fcic-now\/wp-json\/wp\/v2\/posts\/200","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.flinders.edu.au\/fcic-now\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.flinders.edu.au\/fcic-now\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.flinders.edu.au\/fcic-now\/wp-json\/wp\/v2\/users\/1138"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.flinders.edu.au\/fcic-now\/wp-json\/wp\/v2\/comments?post=200"}],"version-history":[{"count":0,"href":"https:\/\/blogs.flinders.edu.au\/fcic-now\/wp-json\/wp\/v2\/posts\/200\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.flinders.edu.au\/fcic-now\/wp-json\/wp\/v2\/media?parent=200"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.flinders.edu.au\/fcic-now\/wp-json\/wp\/v2\/categories?post=200"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.flinders.edu.au\/fcic-now\/wp-json\/wp\/v2\/tags?post=200"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}