{"id":1125,"date":"2020-08-04T09:15:42","date_gmt":"2020-08-03T23:45:42","guid":{"rendered":"http:\/\/blogs.flinders.edu.au\/mdri-news\/?p=1125"},"modified":"2020-08-04T09:19:54","modified_gmt":"2020-08-03T23:49:54","slug":"ideal-way-to-test-biofluids-study-finds","status":"publish","type":"post","link":"https:\/\/blogs.flinders.edu.au\/mdri-news\/2020\/08\/04\/ideal-way-to-test-biofluids-study-finds\/","title":{"rendered":"Ideal way to test biofluids, study finds"},"content":{"rendered":"
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Flinders University Professor Youhong Tang, centre, with PhD Anh Tran Pham, left, Xinyi Zhang (Master of Engineering, Major in Biomedical Engineering), Australia-China Centre for Personal Health Technologies manager Carolyn Ramsey, and Hao Fu, a graduate of Master of Engineering (Electrical and Electronic), Flinders University.<\/div>\n

Every drop of bodily fluid, or biofluid, holds valuable clues to a person\u2019s health.<\/p>\n

The bioprobe industry is rapidly responding to the rising need for fast screening and early detection of diseases via biomarkers in saliva, blood, urine or sweat samples.<\/p>\n

In the pandemic age of telehealth and new technologies, remote site lab or point-of-care (POC) testing of biofluids is a potentially rapid and non-invasive way to test for most diseases \u2013 including COVID-19.<\/p>\n

Now scientists at Flinders University have run tests on the bioprobe industry, recommending the potential of a novel group of bioprobes with aggregation-induced emission (AIE) properties, so-called AIEgens, as being the best way to deliver accurate clinical biomarkers.<\/p>\n

In a new journal article, the researchers recommend rapid and widespread rollout of low-cost, accurate AIE bioprobe applications which can pick up disease biomarkers in very low concentrations.<\/p>\n

\u201cAIE bioprobes supported by portable device are an exciting new method for detecting biomarkers in bodily fluids,\u201d says Flinders University Professor Youhong Tang, from the Australia-China Centre for Personal Health Technologies.\u00a0\u201cIncreasingly, these low cost and convenient technologies will help raise health services in rural areas and developing countries.<\/p>\n

\u201cThis technique can be easily enhanced by commonly available wearable devices such as smartphone data capture and analysis, and data cloud storage,\u201d he says.<\/p>\n

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Results from point-of-care testing can be sent via a secure mobile device.<\/figcaption><\/figure>\n

Several applications of AIE bioprobes, such as paper-based strips and POC devices, are currently under development, and offer potential to be realized simply by use with smartphone data capture and analysis and data cloud storage.<\/p>\n

These low-cost and highly reliable AIE bioprobe applications are beneficial for both early detection of disease and chronic disease management, and may facilitate greater involvement of health care consumers in managing their own care.<\/p>\n

They have good potential accuracy to rapidly analyse biofluids for rapid diagnosis, early detection and management of chronic health conditions, the researchers say.<\/p>\n

\u201cWe need to accelerate AIEgen sensor development for bodily fluids and the development of corresponding analytical and portable devices,\u201d says Xinyi Zhang, lead author on the new\u00a0Materials Chemistry Frontiers<\/em>\u00a0article.<\/p>\n

\u201cAs well as rapid diagnostics, it can also facilitate greater involvement of health care consumers in managing their own care, leading to greater benefits to more people at lower cost to the system.\u201d<\/p>\n

The Medical Device Research Institute at Flinders University is at the forefront of developing point of care devices using this technology, says Carolyn Ramsey, Manager of the Australia-China Centre for Personal Health Technologies.<\/p>\n

\u201cAs well, our partners at Nankai University in China are developing an AIEgen technology to diagnose COVID-19,\u201d she adds.<\/p>\n

The Australia-China Centre for Personal Health Technologies<\/a>\u00a0is a multidisciplinary initiative in medicine, chemistry, biotechnology, engineering and digital health research led by the Flinders University Medical Device Research Institute. La Trobe University, Motherson, Nankai University, South China University of Technology and Shandong Computer Science Centre are partners in the centre.<\/p>\n

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Photo: Pixabay<\/figcaption><\/figure>\n

AIEgen Luminogens for specific biomarkers \u2013 e.g. albumin, a protein produced in chronic kidney disease \u2013 works by lighting up (or fluorescing) in response to the amount of biomarker present in a person\u2019s bodily fluid.<\/p>\n

The new article \u2018Detection of biomarkers in body fluids using bioprobes based on aggregation-induced emission fluorogens<\/a>\u2019 (2020) by Xinyi Zhang, Bicheng Yao, Qi Hu, Yuning Hong, Angus Wallace, Karen Reynolds, Carolyn Ramsey, Anthony Maeder, Richard Reed and Youhong Tang has been published in the\u00a0Materials Chemistry Frontiers<\/em>\u00a0DOI: 10.1039\/D0QM00376J<\/p>\n

The study was supported by the Australia-China Science and Research Fund and Joint Research Centre on Personal Health Technologies.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Flinders University Professor Youhong Tang, centre, with PhD Anh Tran Pham, left, Xinyi Zhang (Master of Engineering, Major in Biomedical Engineering), Australia-China Centre for Personal Health […]<\/p>\n","protected":false},"author":359,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[846],"tags":[],"class_list":["post-1125","post","type-post","status-publish","format-standard","hentry","category-accpht"],"post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/blogs.flinders.edu.au\/mdri-news\/wp-json\/wp\/v2\/posts\/1125","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.flinders.edu.au\/mdri-news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.flinders.edu.au\/mdri-news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.flinders.edu.au\/mdri-news\/wp-json\/wp\/v2\/users\/359"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.flinders.edu.au\/mdri-news\/wp-json\/wp\/v2\/comments?post=1125"}],"version-history":[{"count":0,"href":"https:\/\/blogs.flinders.edu.au\/mdri-news\/wp-json\/wp\/v2\/posts\/1125\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.flinders.edu.au\/mdri-news\/wp-json\/wp\/v2\/media?parent=1125"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.flinders.edu.au\/mdri-news\/wp-json\/wp\/v2\/categories?post=1125"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.flinders.edu.au\/mdri-news\/wp-json\/wp\/v2\/tags?post=1125"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}