Dr Charlotte Toomes is biomedical scientist and early career researcher whose research interests lie in the biology of blood cancers affecting lymphocytes, a type of white blood cell crucial for fighting infections. She has a PhD in targeted therapies and mechanisms of drug resistance in acute lymphoblastic leukaemia, and now works in the Haematology Research Group, where her research focuses on characterising a novel biomarker and potential therapeutic target for multiple myeloma.

 

In 25 words or less, tell us what your research is about?

My current research investigates the mechanisms driving multiple myeloma progression to discover new biomarkers and therapeutic targets, particularly those associated with poor outcomes.

How do you believe your research will impact patient care or public health outcomes?

Despite advancements in therapies over the last few decades, multiple myeloma remains an incurable disease, and survival rates for high-risk multiple myeloma have not significantly improved. People with multiple myeloma typically undergo several lines of therapy and face repeated cycles of relapse. My research aims to make progress towards developing more effective and less toxic treatments, and to characterise biomarkers that can rapidly identify high-risk patients and guide appropriate treatment regimens. The goal of this work is to improve how multiple myeloma is diagnosed and managed, ultimately aiming towards better outcomes and quality of life for people with this disease.

What do you enjoy most about being a researcher?

What I enjoy most about being a researcher is the mix of curiosity, collaboration, and impact. I’m driven by the scientific method and the process of designing precise experiments to unravel the complex molecular and cellular mechanisms that drive cancer. I love working alongside other brilliant scientists and clinicians towards a shared goal, and learning from communities, patients, and carers whose experiences shape our work. The possibility that my research could one day reach the clinic and improve people’s lives is what keeps me motivated every day.

What do you do when you’re not researching?

When I’m not researching, I enjoy spending time outdoors to reconnect with nature and appreciate its beauty and complexity. In the warmer months (especially before the toxic algal bloom started!), you’ll often find me snorkelling or scuba diving, and in the cooler months, I enjoy hiking. I also prioritise spending quality time with friends and family. Being a cancer researcher has deepened my awareness of how unpredictable life can be and the importance of making the most of the time we have with those closest to us.

What advice would you give to aspiring health and medical researchers?

A career in research is constantly evolving and full of learning opportunities. Focus on building your skills and networks and enjoy the freedom of not writing grants while you can! To launch your career successfully, choose a well-funded lab with a strong support system. Be intentional and strategic with your goals, and don’t hesitate to aim high. Surround yourself with inspiring mentors and peers and always be willing to question existing ideas, innovation is key to advancing health and making a real impact.