NIH: National Cancer Institute, US and other funders
Closing Date 05 Feb 20
Funders & programmes
- NIH: National Cancer Institute, US
- NIH: National Institutes of Health, US
The National Cancer Institute invites applications for its programme to assess the rigour and reproducibility of extracellular vesicle-derived analytes for cancer detection (R01 clinical trial not allowed). This supports innovative research projects that focus on the isolation and characterisation of extracellular vesicles (EVs) and their cargo for discovery of predictive biomarkers for risk assessment, detection, diagnosis and prognosis of early cancer. The focus is on promoting rigour and reproducibility research in both the isolation of EVs as well as the computational analysis of the cargo carried in these vesicles. The objective is to:
- develop methods to isolate EVs and to characterise the cargo contained within these vesicles;
- develop sets of standards for evaluating cargo isolated form EVs;
- develop computational tools or new algorithms to integrate the data on the extracellular vesicle cargo;
- develop and test biomarkers and imaging methods for improved detection of early stages of cancer;
- predict progression from preneoplastic lesions and to monitor interventions.
US and foreign for-profit and non-profit organisations and public and private organisations may apply.
Application budgets are not limited but need to reflect the actual needs of the proposed project. The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. The maximum project period is five years.